NFL DFS Monday Night Football picks: Optimal 49ers vs. Cardinals fantasy lineup advice for DraftKings, FanDuel

NFL Week 11 comes to a close with an NFC West rivalry game between Jimmy Garoppolo and the San Francisco 49ers and Colt McCoy and the Arizona Cardinals at Estadio Azteca in Mexico City on Monday Night Football. Kyler Murray (hamstring) is expected to be out, while DeAndre Hopkins (hamstring) is expected to play for Arizona. McCoy will start in place of Murray. The latest 49ers vs. Cardinals odds suggest that this MNF game will be one-sided in favor of San Francisco, making it imperative to hit on the San Francisco players in the MNF NFL DFS player pool when building your MNF NFL DFS strategy. As one of the most dynamic players the NFL has ever seen, should 49ers all-purpose back Christian McCaffrey be considered a must-start player in your NFL DFS lineups and NFL DFS stacks? Or would building around Rondale Moore, Trey McBride, Deebo Samuel, Brandon Aiyuk, George Kittle, James Conner, or Greg Dortch, who all project to be impact classic and showdown NFL DFS picks for Monday Night Football, be a better strategy?

Before making any NFL DFS picks for Cardinals vs. 49ers on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor.

Kaylor is an NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who has been cashing big all season, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.

Kaylor has been spot-on all season, hitting on epic NFL DFS picks like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3), Amari Cooper (7-101-1), Nick Chubb (23 -113-1), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1) Cooper Kupp (14-122), Travis Kelce (7-25-4), Davante Adams (3-124- 2), Justin Fields (179-1-1, 82-1), Diggs again in Week 8 (6-106-1), Chubb (23-101-2) and Cooper (5-131-1) again on MNF in Week 8, Kelce again in Week 9 SNF (10-106), and Derrick Henry (132 total yards, 2 TDs) on Week 11 TNF. Anyone who has followed his picks is way up.

Now, Kaylor has turned his attention to 49ers vs. Cardinals on Monday Night Football Week 11 and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Cardinals vs. 49ers on MNF

One of Kaylor’s favorite DFS picks for the MNF matchup between Arizona and San Francisco is 49ers wide receiver Deebo Samuel. The former South Carolina standout is having a below average annual production-wise (by his lofty standards), but he remains a threat to break off a big play anytime he touches the ball. Kaylor is expecting the 2021 All-Pro to provide some fireworks on Monday night by ripping off multiple explosive plays.

“Deebo Samuel’s role in the 49ers offense seems to have diminished slightly since the arrival of Christian McCaffrey, but this is the week I think he explodes for one of his best games of the season. The Cardinals are beat up on both sides of the ball , and I am expecting them to commit to slowing down McCaffrey, which should open things up for Samuel to record multiple explosive plays and wow the international crowd at Estadio Azteca in Mexico City. I am projecting over 100 total yards and a touchdown for Samuel on MNF,” Kaylor told SportsLine. You can see the rest of Kaylor’s NFL DFS picks here.

How to build NFL DFS lineups for 49ers vs. Cardinals on MNF

Kaylor is also targeting another undervalued value who could explode for huge numbers for Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor’s MNF DFS picks, at SportsLine.

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Monday Night Football? And which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament in 2022, and find out.

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